Antibacterial effects of zinc oxide nanoparticles on Escherichia coli K88

• DOI: 10.5897/ajb11.3703
• Publication Date: 2012-06-05T18:47:59Z
• Authors: Chao Wang
• Keywords: Zinc oxide, nanoparticle, Escherichia coli K88, antibacterial activity, atomic force microscopy (AFM); 02 engineering and technology; 0210 nano-technology; 3. Good health

This study was conducted to evaluate the antibacterial effects of zinc oxide nanoparticles in vitro . Escherichia coli K88 chosen as an indicator pathogenic bacteria, because it could cause diarrhea both children and early-weaned piglets. In this study, characterization examined. Antibacterial activities against E. were evaluated by determining minimum inhibitory concentration (MIC) bactericidal (MBC) observing on values optical density (OD) at 620 nm populations. Results indicate that had strong activity K88. The increased increased. MIC MBC 0.1 0.8 μg/ml, respectively. To mechanisms, atomic force microscopy (AFM) scanning electron (SEM) used observe morphological changes treated with μg/ml nanoparticles. results reveal damage cell membranes, lead leakage cytoplasm kill bacterial cells. Our indicates potentially be reagent treat diseases caused bacteria. Keywords: Zinc oxide, nanoparticle, K88, activity,