Regeneration of Full-Thickness Rotator Cuff Tendon Tear After Ultrasound-Guided Injection With Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Rabbit Model

• DOI: 10.5966/sctm.2015-0040
• Publication Date: 2015-09-15T02:09:55Z
• Authors: Gi-Young Park; Dong Rak Kwon; Sang Chul Lee
• Keywords: Cord lining

Abstract Rotator cuff tendon tear is one of the most common causes chronic shoulder pain and disability. In this study, we investigated therapeutic effects ultrasound-guided human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection to regenerate a full-thickness subscapularis in rabbit model by evaluating gross morphology histology injected motion analysis rabbit's activity. At 4 weeks after UCB-derived MSC injection, 7 10 tears were only partial-thickness tears, 3 remained tears. The size walking capacity at under ultrasound guidance significantly improved compared with same parameters immediately tear. without surgical repair or bioscaffold resulted partial healing rotator model. Histology revealed that MSCs induced regeneration regenerated tissue was predominantly composed type I collagens. contributed repair. results demonstrate effectiveness local into tendon. Significance study suggest blood-derived may be useful conservative treatment for