Effect of daily milk supplementation on serum and umbilical cord blood folic acid concentrations in pregnant Han and Mongolian women and birth characteristics in China.

• DOI: 10.6133/apjcn.2014.23.4.18
• Publication Date: 2014-01-01
• Authors: Yunfeng Li; Na-shun Hu; Xiao-bin Tian; Li Li; Shang‐Ming Wang; Xiang-Bo Xu; Ning Wang; Cui-ge Shi; Jin-Cai Zhu; Jing-Sseng Sun; Jin-Hua Bao; Si-hai Lang; Changjiang Li; D F Fan; Ling Zhang; Bin Zhang; Yu Gao; Bin He; Jiedong Wang; Shucheng Zhang
• Keywords: Cord blood

Many studies have demonstrated the efficacy of folic acid (FA) supplementation in prevention neural tube defects (NTDs), although extent NTDs varies among individuals different races and ethnic origin. China is a multi-ethnic country with no standard practice for FA-fortified food. Milk consumed by women, but little known about effects milk on folate concentration maternal blood neonatal umbilical cord Han Mongolian women after stopping taking supplement month five month, respectively. The objective this study was to determine whether only daily consumption liquid can increase pregnant there are differences concentrations between cessation FA supplementation. Of 4052 enrolled parallel group design study. Three thousand hundred twenty-six had confirmed pregnancies were randomized receive or not until delivery. Women who significantly increased serum at 16 32 weeks gestation as well birth compared control groups both groups. Infants born drinking also better term weight height, which may be related folate. In conclusion, (differences supplementation) enhance outcomes. 许多研究证明补充叶酸能够有效预防神经管畸形，然而不同种族间神经管畸形 的发生程度不同。中国是一个没有实施叶酸强化标准食物的多民族国家，尚不 清楚补充牛奶是否对中国汉族和蒙古族怀孕妇女停止服用叶酸1 个月和5 个月 后的血清和脐带血中叶酸含量有影响。本研究的目的是确定怀孕妇女停止服用 叶酸后，每天补充液体牛奶是否能够增加血液中叶酸的含量，以及汉族和蒙古 族之间是否有差别？4052 名妇女参与了此项研究，其中3526 名妇女被确认怀 孕，随机分为补充牛奶组和不补充牛奶组。结果显示补充牛奶后，无论汉族还 是蒙古族，在孕16 周和32 周及脐带血中的叶酸含量都显著升高。补充牛奶的 妇女所生婴儿的体重和身高都好于未补充牛奶妇女所生的婴儿，这可能和血清 中叶酸浓度的升高有关。总而言之，每天补充牛奶能够提高中国汉族和蒙古族 怀孕妇女血清中的叶酸浓度，并可能改善出生结局。