An Overview on Ibuprofen Derivatives: Advancements in NSAIDs for Enhanced Anti-inflammatory and Analgesic Efficacy

• DOI: 10.62225/2583049x.2024.4.6.3543
• Publication Date: 2024-12-20T04:44:15Z
• Authors: Nisha Gupta; Suchita Wamankar; Anjali .; Gyanesh Kumar Sahu; Rajesh Kumar Nema
• Keywords: Ibuprofen; Anti-inflammatory; Docking (animal); Amide

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are widely used for pain relief and inflammation management. However, their clinical utility is often limited by gastrointestinal side effects arising from non-selective inhibition of both COX-1 COX-2 enzymes. To address this issue, the ibuprofen derivatives with structural modifications aimed at enhancing selectivity while minimizing inhibition. The approach involved incorporating specific functional groups substituents into scaffold to modulate its binding affinity active site. These were guided computational modeling, molecular docking structure-activity relationship (SAR) studies. synthesis novel derivative amide acyl hydrazide derivatives, quinoline conjugate, hydroxyl group or hetero atoms has been investigate help technology. cucumis melo also reported posses anti-ulcer potential study investigated mechanism underlying potential. All molecule showed higher towards Cox-2 enzyme compared traditional have ability mitigate ulcer anti- effect.