Evaluation of Fosfomycin in-vitro susceptibility among gram negative isolates from urine culture in a tertiary care hospital in Lucknow

• DOI: 10.62877/71-ijcbs-24-25-19-71
• Publication Date: 2024-07-16T09:37:24Z
• Authors: Sandeepika Dubey; Areena Hoda Siddiqui; Meenakshi Sharma
• Keywords: Fosfomycin; Gram; Tertiary care; Gram-Negative Bacteria

The rise of bacteria that are Multidrug- resistant or Extended Drug Resistant (MDR XDR) and the lack novel antibiotics have wreaked havoc on patient treatment options. Fosfomycin has just recently come to light because development resistance existing drugs. This study aims evaluate susceptibility Gram- negative isolates in vitro. A prospective done Department Microbiology, Integral Institute Medical Sciences Research, Lucknow, over a period six months from April 2023 September 2023. total 1328 urine samples were processed microbiology lab after identification urinary isolates, antibiotic testing was performed, results interpreted following Clinical Laboratory Standards guidelines (CLSI). sensitivity tested by Kirby-Bauer disc diffusion method. 353 showed growth pathogens. 184 (52.1%) Gram-negative, while 169 (47.8%) Gram-positive. (7%) Nitrofurantoin (13%) lower rates among these isolates. Relatively higher observed for Doripenem (17%), Meropenem Imipenem (18%), Amikacin Gentamicin (27.9%). Norfloxacin, Aztreonam, Cefepime, Ciprofloxacin Levofloxacin Cotrimoxazole high rate 46.2%, 48.8%, 50%, 60.4%, 61% 70% respectively. Fosfomycin's low indicates it works well as antibiotic. Uropathogenic Enterobacteriaceae exhibited an excellent level vitro Fosfomycin. These highlight unexplored possibilities superior therapeutic option UTIs, good chance expanding into safe effective oral alternative can be used inpatient outpatient settings.