NOVEL TARGETED VIOLOGEN FOR THE INDUCTION OF SUPEROXIDE PRODUCTION IN MITOCHONDRIA

• DOI: 10.70200/rx202401041j
• Publication Date: 2024-09-05T08:59:00Z
• Authors: Matea Juric; Bruna Rafaela Per...; Tarun Pant; Adam Sikora; Micael Hardy; Jacek Zielonka
• Keywords: Viologen

<p>Mitochondrial production of O<sub>2</sub><sup>•–</sup> and H<sub>2</sub>O<sub>2</sub> has been implicated in redox signaling and the pathogenesis numerous diseases including cancer, neurodegeneration, cardiovascular diseases. To understand exact role those species, new chemical biology tools for selective efficient induction mitochondrial superoxide are needed. Here, we report development a viologen-based cycling agent, mito-diquat (Mito-DQ), capable inducing targeted O<sub>2</sub><sup>•–</sup> production at significantly higher rates as compared to previously reported mito-paraquat (Mito-PQ), widely used tool study mitochondria-dependent signaling.</p>