Nucleosomal packaging of eukaryotic DNA and regulation of transcription

• DOI: 10.7124/bc.0008bb
• Publication Date: 2014-12-11T23:12:13Z
• Authors: A. K. Golov; S. V. Razin; A. A. Gavrilov
• Keywords: Eukaryotic transcription; Transcription; Transcription coregulator; Transcription bubble; Pioneer factor

The eukaryotic nucleus harbors genomic DNA, which is tens of thousands times greater in linear size than the nuclear diameter.Its high condensation due to DNA packaging chromatin, and wrapping around nucleosomal globules a key step process.A histone octamer, forms globule, interacts with via electrostatic contacts.DNA-histone interactions are rather tight prevent from being accessed by various enzymes transcription factors.At same time, nucleosomes do not other processes related genetic function DNA.The review considers structure diversity central role they play regulating transcription.Special emphasis placed on how internucleosomal contribute genome accessibility machinery removed regulatory elements units controlled manner during elongation.