Clinical and Pathological Factors Influencing the Survival of Breast Cancer Patients with Malignant Pleural Effusion

• DOI: 10.7170/jsis.v1i3.429
• Publication Date: 2012-10-10
• Authors: Giovana Santos; Natália Dressler ...; João Carlos Prolla; Rosicler Mendes; Paulo Henrique Sa...; R. M. T. Fernandes; Jaqueline Pinheiro; Ivana Beatrice Mâ...; Cláudia Giuliano ...
• Keywords: Univariate analysis

INTRODUCTION: in recent decades, we have observed an increasing incidence of breast cancer worldwide. In Brazil, the occurrence rate is estimated at 52, 689 new cases 2012. state Rio Grande do Sul, crude primary cancer, 81, 97 every 100 000 inhabitants, representing Brazilian with second highest cancer. This neoplasm considered a public health problem because its high incidence, morbidity and mortality, cost treatment. Complications triggered by distant metastases may affect many patients who Organs, such as brain, lungs, liver bones are main ones to be likely develop disease due metastases. Lastly, this study aims identify clinical pathological factors that survival history pleural effusion neoplastic. MATERIALS AND METHODS: A cohort study, which exams had malignant from 2006 2010 were analyzed. Throughout these exams, there was search for medical charts, well cytopathological data related tumor metastasis. Statistical analyses done using SPSS 18. 0, carrying out descriptive analyses, curves Kaplan-Meier method Cox univariate analysis. RESULTS: Among 145 patients, 87 (60%) diagnosed positive cells fluid, 119 presented ductal histology. There worse prognosis triple-negative phenotype, showing sharp decline curve, 25 triple- negative 20 (80%) died. Following up sample, it possible observe average 6 months cytological diagnosis fluid. DISCUSSION: relation classified triple-negative, confirming literature data, presenting more aggressive tumor, consequent reduction survival, higher metastasis distant, particularly visceral organs, lung. Studies neoplastic spread present longer interval free indicator prognosis, associated poor factors, as: site expression c-erbB-2, triple-phenotype negative, ki-67 protein expression. CONCLUSIONS: our found phenotype identification unfavorable characteristic indicate reflecting life expectancy. KEYWORDS: effusion, metastatic