Association of Human Epidermal Growth Factor Receptor-2 Expression and Clinicopathological Findings in Patients with Colorectal Cancer

• DOI: 10.7314/apjcp.2012.13.12.6221
• Publication Date: 2013-05-15T05:08:37Z
• Authors: Halit Karaca; Kemal Deniz; Veli Berk; Mevlude Inanc; Metin Ozkan
• Keywords: Perineural invasion; Lymphovascular invasion

Background: To determine the frequency of HER-2 overexpression in colorectal cancer (CRC) patients, and to explore relationship between clinicopathological prognostic factors their effects on survival, based immunohistochemistry (IHC) fluorescent situ hybridization (FISH) analysis. Materials Methods: The study included 80 patients with a histologically proven diagnosis CRC that received adjuvant FOLFOX-4 chemotherapy at our department March 2006 September 2010. Patient data were analyzed retrospectively. Results: median follow-up period age 24 months 59 years, respectively. In immunohistochemical staining, 3+ staining was found 2 (2.5%) while 2+ 13 (16%). FISH for performed all these 15 patients; samples which showed positivity but ones negative. There no significant correlation expression age, gender, tumor localization, histological subtype, grade, lymphovascular perineural invasion, or pTN stage (P>0.05), even when separately. also progression-free survival (PFS) overall (OS), expression, obstruction-perforation, bleeding, type, pT staging (P>0.05); however, there lymph node involvement, PFS OS (P<0.05). Conclusions: Evaluation more comprehensive, multi-center, prospective trial standardized methods will be an appropriate approach.