Reduced Expression of Limd1 in Ulcerative Oral Epithelium Associated with Tobacco and Areca Nut

• DOI: 10.7314/apjcp.2012.13.9.4341
• Publication Date: 2013-02-06T07:03:16Z
• Authors: Guru Prasad Maiti; Amlan Ghosh; Ramdas Chatterjee; Anup Roy; Tyson V. Sharp; Susanta Roychoudhury; Chinmay Kumar Panda
• Keywords: Areca

The aim of this study was to cast light on initiating molecular events associated with the development premalignant oral lesions induced by tobacco and/or areca nut.Immunohistochemical analyses cell cycle regulatory proteins (LIMD1, RBSP3, p16, RB, phosphorylated p53), EGFR and SH3GL2 (EGFR protein) were performed inflammatory/ ulcerative epithelium adjacent hyperplastic/mild dysplastic lesions.No change in expression seen inflammatory epithelium. Reduced nuclear LIMD1 evident In hyperplastic lesions, reduced overexpression p-RB apparent. p53 observed mild lesions.Our data suggest that inactivation might predispose tissues alterations other signaling needed for lesions.