Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells

• DOI: 10.7314/apjcp.2013.14.11.6739
• Publication Date: 2014-03-07T01:00:33Z
• Authors: Zeinab Korany Hassan; Maha Hussein Elamin; Sawsan Ali Omer; Maha Hassan Daghe...; Ebtesam Salah Al-...; Mai AbdelRahman E...; Promy Virk
• Keywords: Oleuropein; MCF-7

Background: Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed assess mechanism oleuropin-induced breast cell apoptosis. Materials and Methods: p53, Bcl-2 Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) luminal MCF-7 cells. Results: Oleuropein-induced accompanied up-regulation both p53 levels down-regulation Bcl2. Conclusions: Oleuropein tumour via p53-dependent pathway mediated Bcl2 genes. Therefore, may have therapeutic potential patients inducing activation pathway.