Association of Matrix Metalloproteinase (MMP)-2 and -9 Expression with Extra-gastrointestinal Stromal Tumor Metastasis

• DOI: 10.7314/apjcp.2014.15.10.4187
• Publication Date: 2014-09-17T07:32:57Z
• Authors: Chao Wang; Hong-Xi Ma; Mei-Shan Jin; Ya-Bin Zou; Yong-Liang Teng; Zhuang Tian; Hai-Ying Wang; Yin-Ping Wang; Xiu-Mei Duan
• Keywords: Adult; Male; 0301 basic medicine; Gastrointestinal Stromal Tumors; Middle Aged; Immunohistochemistry; Up-Regulation; 03 medical and health sciences; Matrix Metalloproteinase 9; Biomarkers, Tumor; Humans; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Neoplasm Metastasis; Aged

Matrix metalloproteinase (MMP)-2 and MMP-9 are important proteases involved in invasion metastasis of various tumors. Extra-gastrointestinal stromal tumors (EGISTs) rare neoplasms. This study was performed to assess MMP-2 expression EGIST tissue samples for association with clinicopathological data from the patients. Twenty-one surgical specimens were collected analysis MMP- 9 using immunohistochemistry. proteins expressed all epithelial cell types EGISTs, whereas they only 75% spindle type, although there no statistically significant difference (p>0.05). Expression associated tumor size, mitotic rate, necrosis, distant (p<0.05). linked levels However, correlation between age, sex, primary site, or morphology any these 21 patients Moreover, increased degree risk. provided evidence an advanced behavior.