Effect of NUCKS-1 Overexpression on Cytokine Profiling in Obese Women with Breast Cancer

• DOI: 10.7314/apjcp.2014.15.2.837
• Publication Date: 2014-07-01T14:40:29Z
• Authors: Nema Ali Soliman; Doaa Hussein Zine...; Osama Helmy El-Kh...
• Keywords: Profiling (computer programming)

Overweight and obesity are recognized as major drivers of cancers including breast cancer. Several cytokines, interleukin-6 (IL-6), IL-10 lipocalin 2 (LCN2), well dysregulated cell cycle proteins implicated in carcinogenesis. The nuclear, casein kinase cyclin-dependent substrate-1 (NUCKS-1), is a nuclear DNA-binding protein that has been several human cancers, cancer.The present study was conducted to evaluate NUCKS-1 mRNA expression tissue from obese patients with without cancer lean controls. correlated cytokine profiles prognostic monitoring tools for cancer, providing molecular basis causal link between risk.This included 39 females (G III) furtherly subdivided into two subgroups according grading IIIa G IIIb) 10 control II) addition age-matched healthy controls I). studied biopsies by means real-time PCR (RT-PCR). Serum were determined immunoassay. Lipid glycemic status anthropometric measures also recorded all participants.IL-6, IL-12 LCN2 significantly higher group than their relevant (p<0.05), while the compared other groups (p<0.05). Significant levels IL-6, IL-12, reported IIIb IIIa, positively markers patients.Evaluation related gene may provide new tool understanding interactions three axes carcinogenesis, innate immunity, inflammation cycling, hope strategies management.