Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

• DOI: 10.7314/apjcp.2014.15.2.945
• Publication Date: 2014-07-01T14:40:29Z
• Authors: Qing-Qing Li; Zhi-Hao Lu; Li Yang; Ming Lu; Xiao-Tian Zhang; Jian Li; Jun Zhou; Xi-Cheng Wang; Ji-Fang Gong; Jing Gao; Jie Li; Yan Li; Lin Shen
• Keywords: Univariate analysis; Absolute neutrophil count; White blood cell; Performance status

To explore the value of systemic inflammatory markers as independent prognostic factors and extent these improve classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy.We studied such circulating white blood cell count its components well that combined to form inflammation-based scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte (PLR), Index (PI) Nutritional (PNI)) in 384 first-line chemotherapy. Univariate multivariate analyses were performed examine impact on overall survival (OS).Univariate analysis revealed an elevated cell, neutrophil and/or platelet count, a decreased lymphocyte low serum albumin concentration, high CRP NLR/PLR , GPS, PI, PNI significant predictors shorter OS. Multivariate demonstrated only (HR 3.696, p=0.003) higher GPS 1.621, p=0.01) poor OS.This study pretreatment be OS GC treated Upon validation data studies, stratification using future clinical trials is recommended.