Single Nucleotide Polymorphisms of DNA Base-excision Repair Genes (APE1, OGG1 and XRCC1) Associated with Breast Cancer Risk in a Chinese Population

• DOI: 10.7314/apjcp.2014.15.3.1133
• Publication Date: 2014-07-10T07:43:03Z
• Authors: Hao Luo; Zheng Li; Yi Qing; Shi-Heng Zhang; Yu Peng; Qing Li; Dong Wang
• Keywords: XRCC1; Chinese population; Korean population

Altered DNA repair capacity can result in increased susceptibility to cancer. The base excision (BER) pathway effectively removes damage caused by ionizing radiation and reactive oxidative species (ROS). In the current study, we analyzed possible relation of polymorphisms BER genes, including 8-oxoguanine glycosylase (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1), X-ray cross-complementing group protein (XRCC1), with breast cancer risk Chinese Han women. This case-control study examined 194 patients 245 cancer-free hospitalized control subjects. Single nucleotide (SNPs) OGG1 (Ser326Cys), XRCC1 (Arg399Gln), APE1 (Asp148Glu -141T/G) were genotyped for their association using multivariate logistic regression models. We found that Arg399Gln was significantly associated an Similarly, Gln allele elevated postmenopausal women a high BMI (≥ 24 kg/m2). Cys provided significant protective effect against developing low (< When analyzing combined effects these alleles on cancer, individuals ≥ 2 adverse genotypes (XRCC1 399Gln, 148Asp, 326Ser) at 2.18-fold (P = 0.027). conclusion, our data indicate 399Gln have genes may contribute tumorigenesis.