Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

• DOI: 10.7314/apjcp.2014.15.8.3555
• Publication Date: 2014-07-10T07:48:14Z
• Authors: Bo Li; Xin Zhao; Shao-Chun Dai; Wen Cheng
• Keywords: Vascularity; Progesterone receptor; Breast ultrasound; Breast imaging; Triple-negative breast cancer

Background: The triple-negative breast cancer (TNBC) is an aggressive characterized by the absence of estrogen receptor (ER), progesterone (PR) and human epidermal growth factor 2 (HER2). Preoperative mammography ultrasound features TNBC may potentially suggest characteristics disease assist in treatment decisions. Materials Methods: study covered 153 patients with from May 2011 to 2012 who were confirmed postoperative pathology results our hospital. We compared radiological findings among sought determine significant iconographic features. biomarkers p53 Ki-67 are regarded as factors TNBC. They therefore used divide into four groups for assessment relationships imaging Results: On mammography, most TNBCs exhibit obscure (44.3%) masses. ultrasound, majority masses (95.4%) predominantly indistinct (50.7%), irregular (76.0%) or featuring posterior echo enhancement/shadowing. Color Doppler flow (CDFI) emphasized hypervascular (32.9%) Differences CDFI statistically (p=0.009). There obvious differences percentages spiculated margin (p=0.049) intensive (p=0.006) spotty between (+) other groups. Conclusions: A combination revealed included mass less attenuated echoes some vascularity. worse prognosis was associated imaging.