Expression Pattern and Prognostic Significance of Claudin 1, 4 and 7 in Pancreatic Cancer

• DOI: 10.7314/apjcp.2015.16.10.4387
• Publication Date: 2015-09-10T14:37:38Z
• Authors: Arsenal Sezgin Al...; Seyda Gunduz; Ozlem Demirpence; Dinc Suren; Umut Riza Gunduz; Cem Sezer; Mustafa Yildiz; Mustafa Yildirim
• Keywords: Male; 0301 basic medicine; Survival; 610; 03 medical and health sciences; Claudin-1; Humans; Claudin-4; Tight junctions; Aged; Aged, 80 and over; Claudin 1; Claudin 4; Pancreatic cancer; Claudin 7; Middle Aged; Prognosis; Neoplasm Proteins; 3. Good health; Pancreatic Neoplasms; Survival Rate; Claudins; Female; Carcinoma, Pancreatic Ductal; Follow-Up Studies

Tight junctions (TJs) organise paracellular permeability and they have an important role in epithelial and endothelial cell polarity and permanence of barrier function. It has been demonstrated that the Claudin family constitutes an important component of them. In this study, we assessed expression patterns of of Claudin1, 4 and 7 and whether they have any relation with prognosis in patients with pancreatic cancer.Expression patterns of Claudin 1,4 and 7 were examined by immunohistochemistry in 25 patients with a histopathological diagnosis of pancreatic cancer using a semiquantitative scoring of the extent and intensity of staining. After grouping the staining scores as low (final score 0-2) and high (final score 3-9) the relation between expression of Claudin 1,4 and 7 and survival was evaluated.There was no significant relation between expression of Claudin 1,4 and 7 and gender and stage. No statistically significant relation was found between Claudin 1 and 4 expression and survival whereas a statistically significant relation was found between decrease in Claudin 7 expression and decrease in survival.Claudins have important functions other than their popular function known as adhesion. Supporting this hypothesis, we found a statistically significant relationship between increased Claudin 7 expression and increased survival time, and this suggests that Claudin 7 may exert different tumorigenic effects in pancreatic cancer other than its well- known adhesion effect.