Evaluation of Inflammation Parameters in Philadelphia Negative Chronic Myeloproliferative Neoplasia Patients

• DOI: 10.7314/apjcp.2015.16.13.5159
• Publication Date: 2015-10-14T02:18:11Z
• Authors: Tuba Hacibekiroglu; Sema Akinci; Abdulkadir Basturk; Besime inal; Tekin Guney; Sule Mine Bakanay; Imdat Dilek
• Keywords: Myeloproliferative neoplasm

Chronic myeloproliferative diseases are clonal stem cell which occur as a result of uncontrollable growth and reproduction hematopoietic cells, the myeloid series source in bone marrow. Recent studies have suggested that chronic inflammation can be triggering factor change neoplasia (CMPN). In our study, we evaluated existence process Philadelphia negative (Ph-)CMPN patients using parameters combination with demographic, laboratory clinical characteristics patients.Demographic characteristics, laboratorial data, thrombosis histories 99 Ph-CMPN patients, who were diagnosed at outpatient clinic hematology accordance WHO 2008 criteria, analyzed retrospectively,with 80 healthy individuals matching gender age included controls. Complete blood counts, sedimentation, C reactive protein (CRP), JAK V617F gene mutations, abdomen ultrasound images previous these retrospectively analyzed.Ph-CMPN control groups cases, respectively. PV, ET MF diagnoses 43 (%43.4), 44 (44.4%) 12 (12.1%), mutation was found to positive 64 (71.1%) all cases 27(65.8%), 32 (82%), 5 (50%) PMF groups, Thrombosis determined (12%) entire group, 12.5% 15.3% no statistical significance (p=0.758). No significant difference observed between without history respect hemogram parameters, sedimentation CRP (p>0.05), neutrophil lymphocyte ratio (NLR), erythrocyte distribution width (RDW), mean platelet volume (MPV) levels patient.