Seroprevalence of Anti-EBV IgG among Various Age Groups from Khon Kaen Province, Thailand

• DOI: 10.7314/apjcp.2015.16.17.7583
• Publication Date: 2016-01-18T02:46:10Z
• Authors: Rabporn Suntornlo...; Nasamon Wanlapakorn; Sompong Vongpunsawad; Thanunrat Thongmee; Jira Chansaenroj; Yong Poovorawan
• Keywords: Seroprevalence; Mononucleosis

Epstein-Barr virus (EBV) is an extremely common herpesvirus that may cause asymptomatic infection or various diseases, including infectious mononucleosis, certain lymphoproliferative diseases and several types of neoplasms. Vaccine development important strategy to reduce the burden EBV-associated timing vaccinations should be before primary occurs. In past, more than 90% Thai children were infected with EBV in early childhood. Now, due improved healthcare system Thailand, we aim determine current prevalence among people different age groups. A total 538 sera collected from residents Khon Kaen province northeastern Thailand for detecting anti-EBV IgG. Sera infants under 2-years-old also tested IgM EBV-DNA. The IgG was 47.1% (95% CI: 23.3-70.8) aged 0-6 months, 34.9% 23.1-46.7) those 6-24 87.9% 79.5-96.3) 3-5 years then maintained at above 95% through adulthood. These seropositivity rates remain similar found a previous study conducted 20 ago. are still exposed age. Therefore, prophylactic vaccine given within first two life.