Evaluation of Several Screening Approaches for Detection of Cervical Lesions in Rural Shandong, China

• DOI: 10.7314/apjcp.2015.16.5.1907
• Publication Date: 2015-10-14T05:52:36Z
• Authors: Li-Ju Zong; You-Zhong Zhang; Xing-sheng Yang; Jie Jiang; Bao-Xia Cui; Yun-Bo Qiao; Li Li; Kan Jiang; Wen-Jing Zhang; Bei-Hua Kong; Keng Shen
• Keywords: Hybrid capture

The study was designed to: (1) investigate the prevalence of high-risk human papillomavirus (HR- HPV) infection and cervical neoplasia; (2) evaluate clinical performance visual inspection with acetic acid/ Lugol's iodine (VIA /VILI), Pap smear, (HR-HPV) DNA test for detecting intraepithelial neoplasia grade 2 or worse (CIN2+) (3) explore appropriate screening approach in rural areas Shandong Province.A total 3,763 eligible women from Yiyuan County Yimeng mountainous Shandong, China, were enrolled underwent HR-HPV testing by Hybrid Capture (HC2), VIA /VILI tests. Women positive any referred to colposcopy biopsy as indicated.The among all 11.1% that healthy 9.9%. In 33 cases CIN1, 16 CIN2, 6 CIN3 but none cancer detected crude CIN2+ 0.58%. For CIN2+, sensitivity testing, VIA/VILI, smear 90.9%, 77.3%, 81.8%, respectively. had best specificity 98.2%, followed 89.4%, VIA/VILI lowest 81.2%. Colposcopy referral rate 11.1%, 18.5%, 2.3%, respectively.Our results suggest alone might be primary low-resource Province, China.