Prognostic Factors and Survival in Acute Myeloid Leukemia Cases: a Report from the Northeast of Iran

• DOI: 10.7314/apjcp.2016.17.3.1547
• Publication Date: 2016-05-17T02:38:43Z
• Authors: Abolghasem Allahyari; Tarane Tajeri; Masoud Sadeghi
• Keywords: Adult; Male; Adolescent; Iran; Middle Aged; Prognosis; Anti-Bacterial Agents; 3. Good health; Survival Rate; Leukemia, Myeloid, Acute; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Amphotericin B; Humans; Female; Aged; Follow-Up Studies; Neoplasm Staging; Retrospective Studies

Acute myeloid leukemia (AML) is a clonal hematopoietic disorder resulting from genetic alterations in normal hematopoietic stem cells. The aim of this study was to evaluate prognostic factors and survival of AML patients in the Northeast of Iran.This retrospective study covered 96 patients with AML referred to Emam Reza Hospital, Mashhad city, Iran, from 2009 to 2015. Age, sex, blood group, type of AML, fever, consumption of amphotericin B, cytogenetic forms and survival were analyzed. Also, WBC, hemoglobin and platelet levels were checked. Mean follow-up was 30.5 months (60.4% mortality). Survival was plotted by GraphPad Prism 5 with Log-rank test.The mean age for all AML patients at diagnosis was 40.4 years (range, 17-77 years). Some 42.7% patients were aged <35 years and 40.6% were male. In all patients, 76% had fever and 50% consumed amphotericin. T(15;17)(q22;q21) had the most prevalence (37.7%) compared to other forms. Out of 92 patients, O+(30.4%) was the most common blood group and AML-M5 (28.3%) the most common subtype. There was a significant difference in survival based on WBC and consumption of amphotericin B (P<0.05).WBC level, fever and consumption of amphotericin B proved to be factors for survival of AML patients. The mean age for patients in Iran is lower than other areas in the World and also survival in this study was higher than in other studies.