L-Thyroxine Therapy in Subclinical Hypothyroidism

• DOI: 10.7326/0003-4819-101-1-18
• Publication Date: 2013-04-12T15:10:48Z
• Authors: DAVID S. COOPER; RACHELLE HALPERN; LAWRENCE C. WOOD; ANN A. LEVIN; E. CHESTER RIDGWAY
• Keywords: Subclinical infection

The indications for treating patients with subclinical hypothyroidism (normal serum thyroxine and free levels, but elevated thyrotrophin levels) are poorly defined. In this study, 33 were randomly assigned in a double-blind manner to receive placebo or L-thyroxine therapy followed 1 year thyroid function tests, lipid measurements, basal metabolic rate systolic time interval determinations, questionnaire on hypothyroid symptoms. group showed no changes peripheral indices of hormone action. the thyroxine-treated group, lipids mean did not change, intervals became normal 5 most abnormal baseline values. Symptoms improved 8 14 receiving 3 12 (p < 0.05). L-Thyroxine may be useful myocardial contractility symptoms consistent mild hypothyroidism, both.