The Obesity Paradox in Type 2 Diabetes Mellitus: Relationship of Body Mass Index to Prognosis

• DOI: 10.7326/m14-1551
• Publication Date: 2015-05-04T22:30:54Z
• Authors: Pierluigi Costanzo; John G.F. Cleland; Pierpaolo Pellicori; Andrew L. Clark; David Hepburn; Eric S. Kilpatrick; Pasquale Perrone-...; Jufen Zhang; Stephen L. Atkin
• Keywords: Interquartile range

Whether obesity is associated with a better prognosis in patients type 2 diabetes mellitus controversial.To investigate the association between body weight and large cohort of followed for prolonged period.Prospective cohort.National Health Service, England.Patients diabetes.The relationship mass index (BMI) without known cardiovascular disease at baseline was investigated. Information on all-cause mortality morbidity (such as acute coronary syndrome, cerebrovascular accidents, heart failure) collected. Cox regression survival analysis, corrected potential modifiers, including risk factors comorbid conditions cancer, chronic kidney disease, lung disease), done.10,568 were median 10.6 years (interquartile range, 7.8 to 13.4). Median age 63 55 71), 54% men. Overweight or obese (BMI >25 kg/m²) had higher rate cardiac events syndrome than those normal (BMI, 18.5 24.9 kg/m²). However, being overweight 25 29.9 lower risk, whereas >30 similar that normal-weight persons. Patients low worst prognosis.Data about cause death not available.In this cohort, who more likely be hospitalized reasons. Being but not.National Institute Research University Hull.