Long-Term Colorectal Cancer Incidence and Mortality After a Single Negative Screening Colonoscopy

• DOI: 10.7326/m19-2477
• Publication Date: 2020-05-25T21:00:37Z
• Authors: Nastazja Dagny Pi...; Marek Bugajski; Paulina Wieszczy; Robert Franczyk; Joanna Didkowska; Urszula Wojciecho...; Malgorzata Pisera; Maciej Rupinski; Jaroslaw Regula; Michal Filip Kami...
• Keywords: Standardized mortality ratio

Current guidelines recommend a 10-year interval between screening colonoscopies, but evidence is limited.To assess the long-term risk for colorectal cancer (CRC) and death from CRC after high- low-quality single negative colonoscopy.Observational study.Polish Colonoscopy Screening Program.Average-risk individuals aged 50 to 66 years who had colonoscopy (no neoplastic findings).Standardized incidence ratios (SIRs) standardized mortality (SMRs) of colonoscopy. High-quality included complete examination, with adequate bowel preparation, performed by endoscopists an adenoma detection rate 20% or greater.Among 165 887 followed up 17.4 years, (0.28 [95% CI, 0.25 0.30]) (0.19 [CI, 0.16 0.21]) were 72% 81% lower, respectively, than in general population. examination resulted 2-fold lower (SIR, 0.13 0.20]) (SMR, 0.10 0.06 0.14]) 0.32 0.29 0.35]; SMR, 0.22 0.18 0.25]). In multivariable analysis, hazard high-quality versus 0.55 (CI, 0.35 0.86) 0 5 0.54 0.38 0.77) 5.1 10 0.46 years. Only did SIR SMR 10.1 follow-up not differ compared earlier observation periods.The population was used as comparison group.A associated reduced yielded profound stable reductions throughout entire follow-up.Polish Ministry Health.