Visualization of viral populations

• DOI: 10.7490/f1000research.1092903.1
• Publication Date: 2013-02-11
• Authors: Armin Töpfer; Veronika Bošková; Martin Däumer; Alexander Thielen; David Seifert; Niko Beerenwinkel
• Keywords: Viral quasispecies; Nucleotide diversity

M ea n qu as is pe ci es e nt ro py Entropy a measure of diversity: Frequency distribution entropy Mean position-wise weighted allel distributions The focus in clinical virology shifts from well-established identification single nucleotide variants to genome-wide probing full-length viral RNA strains, called haplotypes. success antiretroviral HIV treatment heavily depends on the knowledge an intra-patient's population heterogeneity, because diversity and particular, low frequency affect virulence, immune escape, drug resistance. We want visualize such quasispecies learn more its dynamics.