Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

• DOI: 10.7554/elife.14846
• Publication Date: 2016-05-17T00:00:47Z
• Authors: Panayiotis Tsokas; Changchi Hsieh; Yudong Yao; Edith Lesburguères; Emma Jane Claire ...; Andrew Tcherepanov; Desingarao Jothia...; Benjamin Rush Har...; Ling Pan; Bruno Rivard; Robert V Farese; Mini P Sajan; Peter John Bergold; Alejandro Iván He...; James E Cottrell; Harel Z Shouval; André Antonio Fenton; Todd Charlton Sac...
• Keywords: LTP induction; Null allele

PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But memory are maintained without in PKMζ-null mice. Two hypotheses can account for these findings. First, unimportant LTP or Second, essential wild-type mice, mice recruit compensatory mechanisms. We find that whereas increases maintenance PKCι/λ, gene-product closely related PKMζ, Using pharmacogenetic approach, we PKMζ-antisense hippocampus blocks spatial but not the target mRNA. Conversely, PKCι/λ-antagonist disrupts Thus, memory, persistent PKCι/λ activation compensates loss