Satb2 determines miRNA expression and long-term memory in the adult central nervous system

• DOI: 10.7554/elife.17361
• Publication Date: 2016-11-29T13:00:35Z
• Authors: Clemens Jaitner; Chethan Reddy; Andreas Abentung; Nigel Whittle; Dietmar Rieder; Andrea Delekate; Martin Korte; Gaurav Jain; Andre Fischer; Farahnaz Sananbenesi; Isabella Cera; Nicolas Singewald; Georg Dechant; Galina Apostolova
• Keywords: Forebrain; Long-term memory

SATB2 is a risk locus for schizophrenia and encodes DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 almost exclusively expressed in pyramidal neurons of two regions important memory formation, cerebral cortex CA1-hippocampal field. Here we show required key hippocampal functions since deletion from mouse forebrain prevents stabilization synaptic long-term potentiation markedly impairs fear object discrimination memory. At molecular level, find activity BDNF up-regulate Satb2, which itself binds to promoters coding non-coding genes. controls levels large cohort miRNAs, many are implicated plasticity formation. Together, our findings demonstrate critically involved processes underlie consolidation context-linked