Role of protein synthesis and DNA methylation in the consolidation and maintenance of long-term memory in Aplysia

• DOI: 10.7554/elife.18299
• Publication Date: 2017-01-09T13:00:26Z
• Authors: Kaycey Pearce; Diancai Cai; Adam C Roberts; David L Glanzman
• Keywords: Aplysia; Consolidation; Long-term memory

Previously, we reported that long-term memory (LTM) in Aplysia can be reinstated by truncated (partial) training following its disruption reconsolidation blockade and inhibition of PKM (Chen et al., 2014). Here, report LTM induced partial after original consolidation protein synthesis (PSI) begun shortly training. But when PSI occurs during training, cannot subsequently establish LTM. Furthermore, find DNA methyltransferase (DNMT), whether or afterwards, blocks prevents subsequent induction training; moreover, later DNMT eliminates consolidated Thus, the depends on two functionally distinct phases synthesis: an early phase appears to prime LTM; a whose successful completion is necessary for normal expression Both maintenance depend methylation.