Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells

• DOI: 10.7554/elife.50340
• Publication Date: 2020-02-26T15:00:20Z
• Authors: Marina Garrett; Sahar Manavi; Kate Roll; Douglas R Olleren...; Peter A Groblewski; Nicholas D Ponvert; Justin T Kiggins; Linzy Casal; Kyla Mace; Ali Williford; Arielle Leon; Xiaoxuan Jia; Peter Ledochowitsch; Michael A Buice; Wayne Wakeman; Stefan Mihalas; Shawn R Olsen
• Keywords: Stimulus (psychology)

Cortical circuits can flexibly change with experience and learning, but the effects on specific cell types, including distinct inhibitory are not well understood. Here we investigated how excitatory VIP cells in layer 2/3 of mouse visual cortex were impacted by context a behavioral task. Mice learned detection task set eight natural scene images. Subsequently, during 2-photon imaging experiments, mice performed these familiar images three sets novel Strikingly, temporal dynamics activity differed markedly between images: stimulus-driven suppressed stimuli showed ramping when expected omitted from temporally predictable sequence. This prominent suggests that may adopt different modes processing under versus conditions.