Coordination of humoral immune factors dictates compatibility between Schistosoma mansoni and Biomphalaria glabrata

• DOI: 10.7554/elife.51708
• Publication Date: 2020-01-09T13:00:31Z
• Authors: Hongyu Li; Jacob R Hambrook; Emmanuel A Pila; Abdullah A Gharamah; Jing Fang; Xinzhong Wu; Patrick Hanington
• Keywords: Biomphalaria glabrata; Biomphalaria; Schistosoma

Immune factors in snails of the genus Biomphalaria are critical for combating Schistosoma mansoni, predominant cause human intestinal schistosomiasis. Independently, many these play an important role in, but do not fully define, compatibility between model snail B. glabrata, and S. mansoni. Here, we demonstrate association four previously characterized humoral immune molecules; BgFREP3, BgTEP1, BgFREP2 Biomphalysin. We also identify unique determinants plasma mansoni-resistant glabrata that associate with incompatible phenotype. These coordinate to initiate haemocyte-mediated destruction mansoni sporocysts via production reactive oxygen species. The inclusion a BgFREP3-initiated complex includes BgTEP1 almost completely explains resistance this model. Our study unifies independent lines investigation provide more comprehensive understanding system context infection by parasite.