Resident macrophages acquire innate immune memory in staphylococcal skin infection

• DOI: 10.7554/elife.55602
• Publication Date: 2020-07-08T10:00:13Z
• Authors: Reinhild Feuerstein; Aaron James Forde; Florens Lohrmann; Julia Kolter; Neftali Jose Ramirez; Jakob Zimmermann; Mercedes Gomez de...; Philipp Henneke
• Keywords: Staphylococcal Skin Infections; Monocyte; Limiting

Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. most frequent cause soft tissue infections. Dermal macrophages (Mφ) are critical for coordinated defense against invading aureus, yet they have limited life span with replacement by bone marrow derived monocytes. It currently poorly understood whether localized infections persistently alter resident Mφ subset composition resistance to subsequent infection. In strictly dermal infection model we found that mice, which were previously infected showed faster monocyte recruitment, increased bacterial killing improved healing upon secondary However, decreased half-life, thereby limiting duration memory. summary, programmed locally, independently marrow-derived monocytes during staphylococcal leading transiently second