The HIV-1 latent reservoir is largely sensitive to circulating T cells

• DOI: 10.7554/elife.57246
• Publication Date: 2020-10-06T00:00:24Z
• Authors: Joanna A Warren; Shuntai Zhou; Yinyan Xu; Matthew J Moeser; Daniel R MacMillan; Olivia Council; Jennifer Kirchherr; Julia M Sung; Nadia R Roan; Adaora A Adimora; Sarah Joseph; JoAnn D Kuruc; Cynthia L Gay; David M Margolis; Nancie Archin; Zabrina L Brumme; Ronald Swanstrom; Nilu Goonetilleke
• Keywords: CD4-Positive T-Lymphocytes; Male; 0301 basic medicine; Biomedical and clinical sciences; HIV Infections; Virus Replication; immunology; Cohort Studies; Epitopes; Immunology and Inflammation; Biology (General); Phylogeny; Pediatric; Q; R; Middle Aged; Viral Load; Virus Latency; 3. Good health; Biological sciences; Infectious Diseases; Medical Microbiology; HIV/AIDS; Medicine; Female; Infection; hiv cure; Adult; QH301-705.5; Anti-HIV Agents; Science; Immunology; 610; 03 medical and health sciences; Clinical Research; 616; Humans; human; Aged; Biomedical and Clinical Sciences; Health sciences; HIV; T cell; CD8; Good Health and Well Being; inflammation; Mutation; HIV-1; hiv reservoir; Biochemistry and Cell Biology

HIV-1-specific CD8+ T cells are an important component of HIV-1 curative strategies. Viral variants in the reservoir may limit capacity to detect and clear virus-infected cells. We investigated patterns cell escape replication-competent 25 persons living with (PLWH) durably suppressed on antiretroviral therapy (ART). identified all reactive epitopes proteome for each participant sequenced outgrowth viruses from resting CD4+ All non-synonymous mutations were tested their effect size response, a≥50% loss defined as mutation. The majority (68%) harbored no detectable mutations. These findings suggest that circulating PLWH ART could contribute control rebound be targeted boosting