CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis

• DOI: 10.7554/elife.60849
• Publication Date: 2020-11-02T13:00:28Z
• Authors: Cristina Alarcón-...; Alberto Baroja-Mazo; Carlos de Torre-M...; Carlos M Martínez; Juan J Martínez-G...; Helios Martínez-B...; Carlos García-Pal...; Pablo Pelegrin
• Keywords: Extracellular vesicles

P2X7 receptor activation induces the release of different cellular proteins, such as CD14, a glycosylphosphatidylinositol (GPI)-anchored protein to plasma membrane important for LPS signaling via TLR4. Circulating CD14 has been found at elevated levels in sepsis, but exact mechanism sepsis not established. Here, we show first time that extracellular vesicles, resulting net reduction macrophage functionally affects LPS, monophosphoryl lipid A, pro-inflammatory cytokine production. Also, during murine model activity is maintaining biological fluids and decrease its results higher bacterial load exacerbated organ damage, ultimately leading premature deaths. Our data reveal key helping clear because it maintains concentrations circulating infection.