Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development

• DOI: 10.7554/elife.76932
• Publication Date: 2022-02-18T13:00:28Z
• Authors: Jason T Long; Abigail Leinroth; Yihan Liao; Yinshi Ren; Anthony J Mirando; Tuyet Nguyen; Wendi Guo; Deepika Sharma; Douglas Rouse; Colleen Wu; Kathryn Song Eng ...; Courtney M Karner; Matthew J Hilton
• Keywords: Progenitor

Hypertrophic chondrocytes give rise to osteoblasts during skeletal development; however, the process by which these non-mitotic cells make this transition is not well understood. Prior studies have also suggested that stem and progenitor (SSPCs) localize surrounding periosteum serve as a major source of marrow-associated SSPCs, osteoblasts, osteocytes, adipocytes development. To further understand cell hypertrophic contribute or other marrow associated cells, we utilized inducible constitutive chondrocyte lineage tracing reporter mouse models (