Cellular composition and circuit organization of the locus coeruleus of adult mice

• DOI: 10.7554/elife.80100
• Publication Date: 2023-02-03T13:00:36Z
• Authors: Andrew McKinney; Ming Hu; Amber Hoskins; Arian Mohammadyar; Nabeeha Naeem; Junzhan Jing; Saumil S Patel; Bhavin R Sheth; Xiaolong Jiang
• Keywords: Locus coeruleus

The locus coeruleus (LC) houses the vast majority of noradrenergic neurons in brain and regulates many fundamental functions, including fight flight response, attention control, sleep/wake cycles. While efferent projections LC have been extensively investigated, little is known about its local circuit organization. Here, we performed large-scale multipatch recordings adult mouse to profile their morpho-electric properties while simultaneously examining interactions. are diverse could be classified into two major types. fast excitatory synaptic transmission among was not observed our preparation, these mature connected via gap junction at a rate similar early developmental stage comparable other regions. Most electrical connections form between dendrites restricted narrowly spaced pairs or small clusters same type. In addition, more than electrically coupled cell were often identified across cohort from individual multicell recording sets that followed chain-like organizational pattern. assembly thus follows spatial cell-type-specific wiring principle may imposed by unique rule.