Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2

• DOI: 10.7554/elife.84492
• Publication Date: 2023-01-26T13:00:22Z
• Authors: Liangyu Zhang; Weston T Stauffer; John S Wang; Fan Wu; Zhouliang Yu; Chenshu Liu; Hyung Jun Kim; Abby F Dernburg
• Keywords: Synapsis; Synaptonemal complex; Chromosomal crossover

Meiotic chromosome segregation relies on synapsis and crossover (CO) recombination between homologous chromosomes. These processes require multiple steps that are coordinated by the meiotic cell cycle monitored surveillance mechanisms. In diverse species, failures in can trigger a delay and/or lead to apoptosis. How this key step ‘homolog engagement’ is sensed transduced cells unknown. Here we report C. elegans , recruitment of Polo-like kinase PLK-2 synaptonemal complex triggers phosphorylation inactivation CHK-2, an early required for pairing, synapsis, double-strand break (DSB) induction. Inactivation CHK-2 terminates DSB formation enables CO designation progression. findings illuminate how ensure accurate segregation.