Neurofeedback training can modulate task-relevant memory replay rate in rats

• DOI: 10.7554/elife.90944
• Publication Date: 2023-09-12T19:39:15Z
• Authors: Anna K Gillespie; Daniela Astudillo...; Eric L Denovellis; Sachi Desse; Loren M Frank
• Keywords: Male; Neurons; 0301 basic medicine; hippocampus; QH301-705.5; Science; Q; R; neurofeedback; Neurofeedback; sharp wave ripples; Hippocampus; Rats; memory; 03 medical and health sciences; replay; Memory; Medicine; Animals; Biology (General); Neuroscience; Memory Consolidation

Hippocampal replay – the time-compressed, sequential reactivation of ensembles neurons related to past experience is a key neural mechanism memory consolidation. Replay typically coincides with characteristic pattern local field potential activity, sharp-wave ripple (SWR). Reduced SWR rates are associated cognitive impairment in multiple models neurodegenerative disease, suggesting that clinically viable intervention promote SWRs and would prove beneficial. We therefore developed neurofeedback paradigm for rat subjects which detection triggered rapid positive feedback context memory-dependent task. This training protocol increased prevalence task-relevant during targeted period by changing temporal dynamics occurrence. increase was also behavioral forms compensation after period. These findings reveal short-timescale regulation generation demonstrate an effective strategy modulating hippocampal replay.