Long noncoding RNA <i>lnc_217</i> regulates hepatic lipid metabolism by modulating lipogenesis and fatty acid oxidation

• DOI: 10.7555/jbr.37.20230075
• Publication Date: 2023-06-03T07:13:55Z
• Authors: Xiaoqing Yuan; Yawei Liu; Xule Yang; Yun Huang; Xuan Shen; Hui Liang; Hongwen Zhou; Qian Wang; Xu Zhang; John Zhong Li
• Keywords: Lipogenesis; Steatosis

Nonalcoholic fatty liver disease (NAFLD) is considered a major health epidemic with an estimated 32.4% worldwide prevalence. No drugs have yet been approved and therapeutic nodes remain unmet need. Long noncoding RNAs are emerging as important class of novel regulators influencing multiple biological processes the pathogenesis NAFLD. Herein, we described long RNA, lnc_217, which was enriched upregulated in high-fat diet-fed mice, genetic animal model We found that specific knockdown lnc_217 resistant to diet-induced hepatic lipid accumulation decreased serum mice. Mechanistically, demonstrated not only de novo lipogenesis by inhibiting sterol regulatory element binding protein-1c cleavage but also increased acid β-oxidation through activation peroxisome proliferator-activated receptor α carnitine palmitoyltransferase-1α. Taken together, conclude may be regulator metabolism potential target for treatment steatosis NAFLD-related metabolic disorders.