Intranodal signal suppression in pelvic MR lymphography of prostate cancer patients: a quantitative comparison of ferumoxtran-10 and ferumoxytol

• DOI: 10.7717/peerj.2471
• Publication Date: 2016-10-20T08:31:38Z
• Authors: Oscar A. Debats; Ansje S. Fortuin; Hanneke J.M. Meijer; Thomas Hambrock; Geert J.S. Litjens; Jelle O. Barentsz; Henkjan J. Huisman
• Keywords: Ferumoxytol

The key to MR lymphography is suppression of T2* signal in normal lymph nodes, while retaining high metastatic nodes. Our objective quantitatively compare the ability ferumoxtran-10 and ferumoxytol suppress pelvic nodes.In 2010, a set consecutive patients who underwent intravenous Lymphography (MRL) were included. Signal nodes T2*-weighted images due uptake USPIO (Ultra-Small Superparamagnetic Particles Iron Oxide) was quantified. by two contrast agents, compared using Wilcoxon's signed rank test.Forty-four included, which all 44 had MRL 4 additionally MRL. A total 684 identified images, 174 been diagnosed as metastatic. USPIO-induced significantly stronger than (p < 0.005).T2* with ferumoxytol, may affect diagnostic accuracy.