Identification of biological pathways and genes associated with neurogenic heterotopic ossification by text mining

• DOI: 10.7717/peerj.8276
• Publication Date: 2020-01-03T05:05:53Z
• Authors: Yichong Zhang; Yuanbo Zhan; Yuhui Kou; Xiaofeng Yin; Yanhua Wang; Dianying Zhang
• Keywords: Identification; Biological pathway

Neurogenic heterotopic ossification is a disorder of aberrant bone formation affecting one in five patients sustaining spinal cord injury or traumatic brain (SCI-TBI-HO). However, the underlying mechanisms SCI-TBI-HO have proven difficult to elucidate. The aim present study identify most promising candidate genes and biological pathways for SCI-TBI-HO. In this study, we used text mining generate potential explanations Moreover, employed several additional datasets, including gene expression profile data, drug data tissue-specific explore that associated with We identified four SCI-TBI-HO-associated genes, GDF15, LDLR, CCL2, CLU. Finally, using enrichment analysis, pathways, integrin signaling, insulin pathway, internalization ErbB1, urokinase-type plasminogen activator uPAR-mediated PDGFR-beta signaling EGF receptor (ErbB1) class I PI3K events, which may be These results enhance our understanding molecular offer new leads researchers innovative therapeutic strategies.