Effect of 1, 25-Dihydroxy Vitamin D3 on the Expression of Interleukin (IL)-17 and IL-21 in Asthma Mice Model

• DOI: 10.7727/wimjopen.2015.161
• Publication Date: 2015-04-14T20:37:46Z
• Authors: R Lin; J Guo; R Guan; S Hu
• Keywords: Interleukin 1β

Bronchial asthma is a common respiratory disease.It estimated that there are about 300 million people worldwide suffering from asthma.In some countries such as Britain, Australia and New Zealand, the prevalence rate of high 20% (1).T cells, especially CD4 + T mainly including Th1, Th2, Th17 Treg subsets, have been known to play an important immunoregulatory role in pathogenesis asthma.Th17 cell new subset helper cells found recent years, named for its production interleukin (IL)-17.It widely involved immune response (2).Interleukin-21 newly discovered cytokine, which can also be produced by cells.It has better inhibitory than IL-6 pathogenic inflammatory (3).1,25-dihydroxy vitamin D 3 (1,25(OH) 2 ) active form D, formed D3 catalysed 25-hydroxylase 1α-hydroxylase.1,25-dihydroxy binds receptor on target organs subsequently activates downstream molecules, playing corresponding biological effect (4, 5).It reported 1,25(OH) effects all subsets bronchial asthma.For instance, classical mechanism Th1/Th2 cellular imbalance asthma, not only inhibit proliferation Th1 reduce levels interferon gamma (IFN-γ), IL-2 IL-5 (6, 7), but promote expression Th2 cytokines IL-4 IL-13, leading Th2-dominant (8).In addition, differentiation increase serum IL-10 transforming growth factor beta 1 (TGF-β1) levels.In allergic airway