Interaction of diagnostic ultrasound with synthetic oligonucleotide-labeled perfluorocarbon-exposed sonicated dextrose albumin microbubbles.

• DOI: 10.7863/jum.1996.15.8.577
• Publication Date: 2017-01-10T00:36:05Z
• Authors: T R Porter; P L Iversen; S Li; F Xie
• Keywords: Sonication

The purpose of this study was to determine, first, whether the albumin on perfluorocarbon-exposed sonicated dextrose microbubbles has retained its known ability bind antisense oligonucleotides (DNA utilized inhibit viral replication and intimal hyperplasia). binding kinetics synthetic as well room air-containing were compared. Second, effect diagnostic ultrasound is unknown. release from also tested in vitro vivo three dogs. Synthetic exhibited much like that native but did not uniformly with microbubbles. Diagnostic resulted significant partitioning into non-bubble containing regions after insonation deposition greater amounts insonated kidney intravenous injections anti-sense oligonucleotide-labeled We conclude microbubbles, unlike have bioactive their surface can then them presence ultrasound.