Coexpression of COX-2 and iNOS in Angiogenesis of Superficial Esophageal Squamous Cell Carcinoma

• DOI: 10.9738/intsurg-d-14-00234.1
• Publication Date: 2015-04-15T20:49:52Z
• Authors: Youichi Kumagai; Jun Sobajima; Morihiro Higashi; Toru Ishiguro; Minoru Fukuchi; Keiichiro Ishibashi; Erito Mochiki; Koji Yakabi; Tatsuyuki Kawano; Jun-ichi Tamaru; Hideyuki Ishida
• Keywords: Lamina propria; Microvessel

Using immunohistochemical staining, the present study was conducted to examine whether cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) affect angiogenesis in early-stage esophageal squamous cell carcinoma (ESCC). We also analyzed correlation between these two factors. Cyclooxygenase 2, iNOS, ESCC are unclear. 10 samples of normal epithelium, 7 low-grade intraepithelial neoplasia (LGIN), 45 superficial cancer, we observed expression COX-2 iNOS. then investigated iNOS immunoreactivity scores or microvessel density (MVD) using CD34 CD105. The intensity differed significantly according histological type (P < 0.001). were lowest for followed ascending order by LGIN, situ tumor invading lamina propria mucosae (M1-M2 cancer); muscularis mucosa (M3) deeper cancer. differences significant Cancers classified M1-M2 0.01 P 0.05, respectively); M3; cancer 0.01) had higher than epithelium. There a 0.001, rs = 0.51). Correlations score CD34-positive MVD CD105-positive (rs 0.53, 0.001; 0.62, respectively). Inducible correlated with CD105 0.45, 0.60, Chemoprevention activity may blunt development from precancerous lesions.