Role of Glutamate Receptor-related Biomarkers in the Etiopathogenesis of ADHD

• DOI: 10.9758/cpn.23.1056
• Publication Date: 2023-06-26T07:12:39Z
• Authors: Ebru Ulu; Esra Demirci; Elif Funda Sener; Sevgi Özmen; Melike Kevser Gul; Reyhan Tahtasakal; Fatma Dal
• Keywords: Cyclin-dependent kinase 5; Pathophysiology

: Pathways associated with glutamate receptors are known to play a role in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). However, cyclin-dependent kinase 5 (CDK5), microtubule-associated protein-2 (MAP2), guanylate kinase-associated protein (GKAP), and postsynaptic density 95 (PSD95), all which biomarkers involved neurodevelopmental processes closely related glutamatergic pathways, have not previously been studied patients ADHD. The main purpose this study was evaluate plasma levels CDK5, MAP2, GKAP, PSD95 children ADHD investigate whether these markers etiology