A5026829268- Bladder and Urothelial Cancer Treatments
- Dialysis and Renal Disease Management
- Peptidase Inhibition and Analysis
- Infective Endocarditis Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Cancer Research and Treatments
- Attention Deficit Hyperactivity Disorder
- Bacteriophages and microbial interactions
- Cancer, Stress, Anesthesia, and Immune Response
- Chemical Reactions and Isotopes
- Protein Degradation and Inhibitors
- Hormonal and reproductive studies
- Clostridium difficile and Clostridium perfringens research
- Diabetes and associated disorders
- Nosocomial Infections in ICU
- Bacterial Genetics and Biotechnology
- Pharmacology and Obesity Treatment
- Cancer Immunotherapy and Biomarkers
- Streptococcal Infections and Treatments
- Kidney Stones and Urolithiasis Treatments
- Hydrogen's biological and therapeutic effects
- Pediatric Urology and Nephrology Studies
- Immune cells in cancer
- Digestive system and related health
Lund University
2020-2025
Universiti Putra Malaysia
2013-2015
Abstract Identifying specific inhibitors of the MYC oncogene has been challenging, due to off target effects associated with inhibition. This study investigated how recombinant Escherichia coli Lon protease (rLon), which targets in human cells, inhibits over-activation models infection and cancer. In silico predictions identified peptide domains bacterial that affinity these peptides for was by surface plasmon resonance. The N-terminal domain rLon shown interact C-terminal, leucine zipper...
Abstract Background The molecular content of urine is defined by filtration in the kidneys and local release from tissues lining urinary tract. Pathological processes different therapies change composition a variety markers have been analyzed patients with bladder cancer. response to BCG immunotherapy chemotherapy has extensively studied elevated concentrations IL‐1RA, IFN‐α, IFN‐γ TNF‐α, IL‐17 associated improved outcome. Methods In this study, host intravesical alpha 1‐oleate treatment was...
Abstract Background The tumoricidal complex alpha1‐oleate targets bladder cancer cells, triggering rapid, apoptosis‐like tumor cell death. Clinical effects of were recently observed in patients with non‐muscle invasive (NMIBC), using a randomized, placebo‐controlled study protocol. Aims To investigate if there are dose‐dependent alpha1‐oleate. Materials and Methods Here, NMIBC treated by intravesical instillation increasing concentrations (1.7, 8.5, or 17 mM) the treatment response was...
Unlike pathogens, which attack the host, commensal bacteria create a state of friendly coexistence. Here, we identified mechanism bacterial adaptation to host niche, where they reside. Asymptomatic carrier strains were shown inhibit RNA polymerase II (Pol II) in cells by targeting Ser2 phosphorylation, step required for productive mRNA elongation. Assisted rare, spontaneous loss-of-function mutant from human carrier, NlpD protein was as Pol inhibitor. After internalization cells, target...
Innate immunity is essential for the anti-microbial defense, but excessive immune activation may cause severe disease. In this study, immunotherapy was shown to prevent innate and restore anti-bacterial defense. E. coli-infected Asc−/− mice develop acute cystitis, defined by IL-1 hyper-activation, high bacterial counts, extensive tissue pathology. Here, interleukin-1 receptor antagonist (IL-1RA), which inhibits hyper-activation in identified as a more potent inhibitor of inflammation NK1R-...
Though new targeted therapies for colorectal cancer, which progresses from local intestinal tumors to metastatic disease, are being developed, tumor specificity remains an important problem, and side effects a major concern. Here, we show that the protein-fatty acid complex BAMLET (bovine alpha-lactalbumin made lethal cells) can act as peroral treatment cancer. ApcMin/+ mice, carry mutations relevant hereditary sporadic human received in drinking water showed long-term protection against...
This study investigated the molecular basis of disease severity in acute pyelonephritis (APN), a common and potentially life-threatening bacterial infection. Two cohorts infants with febrile urinary tract infection were included. Renal involvement was defined by DMSA scans determinants gene expression analysis proteomic screens, at diagnosis after 6 mo. Innate immune hyper-activation, systemically locally tract, as cytokine storm. Neutrophil degranulation renal toxicity genes strongly...