A5022408565- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- biodegradable polymer synthesis and properties
- Neurological disorders and treatments
- S100 Proteins and Annexins
- Tryptophan and brain disorders
- Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
University of Cambridge
2019-2022
AstraZeneca (United Kingdom)
2021
University of Edinburgh
2017
In addition to motor neurone degeneration, up 50% of amyotrophic lateral sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these deficits is critical, as cognitively impaired exhibit a shorter survival time from symptom onset. Given pathogenic role synapse loss in other neurodegenerative diseases which decline apparent, such Alzheimer's disease, we aimed assess synaptic integrity ALS brain. Here, have applied unique combination...
Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer's disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated species contribute to progression are not fully determined. As analysis human cerebrospinal fluid (CSF) provides an accessible window into molecular changes progression, we characterised soluble present CSF samples from individuals AD, mild cognitive impairment (MCI) healthy controls using...
Protein aggregation likely plays a key role in the initiation and spreading of Alzheimer's disease pathology through brain. Soluble aggregates amyloid beta are believed to play this process. However, present humans still poorly characterized due lack suitable methods required for characterizing low concentration heterogeneous present. We have used variety biophysical characterize human brains at Braak stage III. find soluble beta-containing all regions brain up 200 nm length, capable causing...
Abstract Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer’s disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated species contribute to progression are not fully determined. As analysis human cerebrospinal fluid (CSF) provides an accessible window into molecular changes progression, we studied soluble Aβ present CSF samples from individuals AD, mild cognitive impairment (MCI) healthy...