A5059926741- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Ginkgo biloba and Cashew Applications
- Telomeres, Telomerase, and Senescence
- Atherosclerosis and Cardiovascular Diseases
- Sex and Gender in Healthcare
- Gastric Cancer Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Gastrointestinal Tumor Research and Treatment
- Renin-Angiotensin System Studies
- Nutritional Studies and Diet
- Colorectal Cancer Treatments and Studies
- Cardiovascular Disease and Adiposity
- Metabolism and Genetic Disorders
- Hormonal Regulation and Hypertension
- Genetics, Aging, and Longevity in Model Organisms
- Multiple Sclerosis Research Studies
- Microbial Metabolites in Food Biotechnology
- Assembly Line Balancing Optimization
- Adipose Tissue and Metabolism
- Powdery Mildew Fungal Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Charité - Universitätsmedizin Berlin
2014-2023
Humboldt-Universität zu Berlin
1997-2023
Freie Universität Berlin
2017-2023
German Centre for Cardiovascular Research
2013-2023
Deutsches Herzzentrum der Charité
2023
Chemnitz University of Technology
2022
Johannes Gutenberg University Mainz
2021
University Hospital Frankfurt
2019
Goethe University Frankfurt
2019
Institut Kurz
2015
Epidemiological studies suggest that tea catechins may reduce the risk of cardiovascular disease, but mechanisms benefit have not been determined. The objective present study was to investigate effects epigallocatechin-3-gallate (EGCG), major constituent green tea, on vasorelaxation and eNOS expression activity in endothelial cells. EGCG (1-50 μm) induced dose-dependent vasodilation rat aortic rings. Vasodilation abolished by pretreatment with NG-nitro l-arginine methyl ester. In bovine...
There is good evidence that telomere shortening acts as a biological clock in human fibroblasts, limiting the number of population doublings culture can achieve. Oxidative stress also limits growth potential cells, and recent data show effect mild oxidative mediated by stress-related increased rate shortening. Thus, fibroblast strains have donor-specific antioxidant defense, rate, potential. We used low-density gene expression array analysis with different potentials rates to identify...
Aims Experimental and clinical studies indicate that tea exerts protection against cardiovascular diseases. However, a question of much debate is whether addition milk modifies the biological activities tea. We studied vascular effects tea, with or without milk, in humans elucidated impact individual proteins cell culture experiments, isolated rat aortic rings by HPLC analysis. Methods results A total 16 healthy female volunteers consumed either 500 mL freshly brewed black 10% skimmed boiled...
Causal therapeutic approaches for amyloid diseases such as Alzheimer's and Parkinson's disease targeting toxic oligomers or fibrils are still emerging. Here, we show that theaflavins (TF1, TF2a, TF2b, TF3), the main polyphenolic components found in fermented black tea, potent inhibitors of amyloid-β (Aβ) α-synuclein (αS) fibrillogenesis. Their mechanism action was compared to two established formation, (-)-epigallocatechin gallate (EGCG) congo red (CR). All three compounds reduce...
The ubiquitin-proteasome system is the major pathway for intracellular protein degradation in eukaryotic cells. Endothelial nitric oxide synthase (eNOS) key enzyme of vascular homeostasis involved pathophysiology several cardiovascular diseases. aim our study was to investigate whether eNOS expression and activity are regulated by proteasome. Bovine pulmonary artery endothelial cells (CPAE cells) were treated with proteasome inhibitor MG132. MG132 (50-250 nmol/L) dose-dependently increased...
Consumption of tea has been shown to improve endothelial function. It is assumed that catechins are the components responsible for these beneficial effects. In black tea, catechin concentrations significantly lower than in green tea. The present study was designed compare and with regard amelioration Endothelial function response both teas assessed bovine aortic cells (BAEC) rat rings. To elucidate whether findings also applicable humans, flow-mediated dilation (FMD) nitro-mediated (NMD)...
Neurodegenerative disorders show an increasing prevalence in a number of highly developed countries. Often, these diseases require life-long treatment mostly with drugs which are costly and accompanied by more or less serious side-effects. Their heterogeneous manifestation, severity outcome pose the need for individualised options. There is intensive search new strategies not only treating but also preventing diseases. Green tea green extracts seem to be such promising safe alternative....
There is growing evidence that a cross-talk exists between the renin-angiotensin (Ang) system and lipoproteins. We investigated role of high-density lipoprotein (HDL) on Ang II type 1 receptor (AT1R) regulation subsequent II–mediated signaling under diabetic conditions. To investigate effect HDL AT1R expression in vivo, apolipoprotein A-I gene transfer was performed 5 days after streptozotocin injection. Six weeks transfer, 1.9-fold ( P =0.001) increase cholesterol associated with 4.7-fold...
Background Lycopene is the main carotenoid in tomatoes, where it found high concentrations. Strong epidemiological evidence suggests that lycopene may provide protection against cardiovascular diseases. We therefore studied effects of on diet-induced increase serum lipid levels and initiation atherosclerosis New Zealand White (NZW) rabbits. Methodology/Principal Findings The animals, divided into four groups 9 animals each, were fed either a standard diet, high-cholesterol diet containing...