A5048923386- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Carbon Nanotubes in Composites
- Macrophage Migration Inhibitory Factor
- Immune cells in cancer
- RNA Research and Splicing
- Diabetic Foot Ulcer Assessment and Management
- RNA and protein synthesis mechanisms
- Nanoparticle-Based Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Diamond and Carbon-based Materials Research
- Reproductive tract infections research
- Wound Healing and Treatments
- NF-κB Signaling Pathways
- Pregnancy and preeclampsia studies
- RNA Interference and Gene Delivery
- Eicosanoids and Hypertension Pharmacology
- Cervical Cancer and HPV Research
- Viral Infections and Immunology Research
- Cellular transport and secretion
- Gut microbiota and health
- Ion-surface interactions and analysis
University of Groningen
2022-2024
University Medical Center Groningen
2024
National MS Center Melsbroek
2023
Biotechnology Institute
2023
Hasselt University
2023
Radboud University Nijmegen
2022
Radboud University Medical Center
2022
Pathological conditions associated with dysfunctional wound healing are characterized by impaired remodelling of extracellular matrix (ECM), increased macrophage infiltration, and chronic inflammation. Macrophages also play an important role in as they drive closure secretion molecules like transforming growth factor beta-1 (TGF-β). As the functions macrophages regulated their metabolism, local administration small that alter this might be a novel approach for treatment wound-healing...
To mount an adaptive immune response, dendritic cells must migrate to lymph nodes present antigens T cells. Critical 3D migration is the nucleus, which size-limiting barrier for through extracellular matrix. Here, we show that inflammatory activation of leads nucleus becoming spherically deformed and enables overcome typical 2- 3-μm diameter limit gaps in We nuclear shape change partially attained reduced cell adhesion, whereas improved achieved reprogramming actin cytoskeleton....
Free radical generation plays a key role in many biological processes including cell communication, maturation, and aging. In addition, free is usually elevated cells under stress as the case for different pathological conditions. liver tissue, produce radicals when exposed to toxic substances but also, instance, cancer, alcoholic disease cirrhosis. However, are small, short-lived, occur low abundance making them challenging detect especially time resolve, leading lack of nanoscale...
Abstract Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into central nervous system (CNS) play a crucial role in initiation of demyelination and neurodegeneration multiple sclerosis (MS). Recently, extracellular vesicles (EV) secreted by BBB endothelial cells (BBB-EC) have emerged as unique form cell-to-cell communication that contributes to cerebrovascular dysfunction. However, precise impact different size-based subpopulations BBB-EC-derived EV (BBB-EV) on early stages...
Abstract To mount an adaptive immune response, dendritic cells must process antigens, migrate to lymph nodes and form synapses with T cells. Critical 3D migration mechano-sensing is the nucleus, which size-limiting barrier for navigation through gaps in extracellular matrix. Here, we show that inflammatory activation of leads nucleus becoming spherically deformed, adopting a raison-like shape enables overcome typical 2 – 3-micron pore limit 3D-migration. We nuclear shape-change partially...
The identification of pseudo- and N1 -methylpseudo-uridine (Ψ mΨ, respectively) as immunosilent uridine analogues has propelled the development mRNA-based vaccines therapeutics. Here, we have characterised another analogue, 5-ethynyluridine (EU), which an ethynyl moiety. We show that this analogue does not cause immune activation in human macrophages, it induce interleukin-6 secretion or expression inflammatory antiviral genes MX1, PKR, TAP2. Moreover, EU allows for prolonged expression,...
To mount an adaptive immune response, dendritic cells must process antigens, migrate to lymph nodes and form synapses with T cells. Critical 3D migration mechano-sensing is the nucleus, which size-limiting barrier for navigation through gaps in extracellular matrix. Here, we show that inflammatory activation of leads nucleus becoming spherically deformed, enables overcome typical 2 – 3-micron pore limit 3D-migration. We nuclear shape-change partially attained reduced cell adhesion, whereas...