A5066427123- Nutritional Studies and Diet
- Sodium Intake and Health
- Blood Pressure and Hypertension Studies
- Synthesis of heterocyclic compounds
- Receptor Mechanisms and Signaling
- Synthesis and Reactions of Organic Compounds
- Pharmacological Receptor Mechanisms and Effects
- Hemoglobin structure and function
- Cardiovascular Health and Disease Prevention
- Neuroscience and Neuropharmacology Research
- Food composition and properties
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Obesity, Physical Activity, Diet
- Synthesis and Biological Evaluation
- Cholesterol and Lipid Metabolism
- Synthesis of β-Lactam Compounds
- Advanced Chemical Physics Studies
- Chemistry and Chemical Engineering
- Coffee research and impacts
- Oxidative Organic Chemistry Reactions
- Antioxidant Activity and Oxidative Stress
- Pharmacological Effects and Assays
- Spectroscopy and Quantum Chemical Studies
- Solid-state spectroscopy and crystallography
Nestlé (Switzerland)
2015-2024
Nestlé (China)
2019
University of Lausanne
2016
Nerve Centre
2007
Centre National de la Recherche Scientifique
1997
Université Libre de Bruxelles
1973-1984
Background & aimsPolyphenol intake has been linked to improvements in human vascular function, although data on hydroxycinnamates, such as chlorogenic acid (CGA) have not yet studied. We aimed investigate the impact of coffee rich function and whether CGAs are involved potential effects.MethodsTwo acute randomized, controlled, cross-over intervention trials were conducted. The intake, matched for caffeine but differing CGA content (89, 310 mg) flow-mediated dilatation (FMD) was assessed 15...
The UK currently has the most detailed, directly measured data for food wasted in home. This includes information on exact types of wasted. These allow calculation nutrients within that waste, as well its environmental impact. results progress conversation beyond how much is or energy content; it permits implications nutrition and sustainability to be assessed detail. Data household waste were expressed an average per capita each type food. Each was matched with item (or group items) from...
Coffee is a rich source of polyphenols, primarily chlorogenic acids (CGA).
Abstract This paper describes the structure determinations of two new ichthyotoxic bis‐quinolizidine alkaloids from marine sponge Petrosia seriata . The structural elucidations are mostly based on homonuclear 2D‐ 1 H NMR experiments.
The σ<sub>2</sub>-receptor agonist, ifenprodil, was suggested as an inhibitor of G protein-coupled inwardly rectifying potassium channels. Nevertheless, analysis the role σ<sub>2</sub> receptors in cardiac electrophysiology has never been done. This work aims i) to identify roles regulation K<sup>+</sup> channel conductances and ii) check whether agonists exhibit class III antiarrhythmic properties. <i>threo</i>-ifenprodil, LNP250A...
Abstract L'étude RMN 13 C de composés époxybicyclo[2.2.1]‐heptaniques fait ressortir une forte influence l'orientation endo ou exo l'hétérocycle sur le glissement chimique du pontal. La différence entre les variations glissements chimiques en et 1 H montre que l'effet courant cycle ne peut seul rendre compte des résultats observés.
BackgroundEpidemiological studies have reported lower risk of cardiovascular disease with moderate coffee consumption. In addition, emerging evidence indicates that consumption beverages enriched in chlorogenic acids (CGAs) may influence blood pressure and endothelial function, suggesting the beneficial effect relate to its CGA content.
The effects of the putative serotonin (5-HT)1A receptor antagonists WAY-100135 (WAY) and spiperone on neuronal activity recorded from medullary dorsal raphe 5-HT neurons inferior cardiac sympathetic nerve were investigated in chloralose anesthetized cats. We also determined effectiveness WAY to antagonize sympathoinhibitory 5-HT1A agonist 8-hydroxy-(2-di-n-propylamino)tetralin (8-OH DPAT). Intravenous administration both produced a dose-related inhibition firing neurons. inhibited...
To model the long-term cost-effectiveness of consuming milk powder fortified with potassium to decrease systolic blood pressure (SBP) and prevent cardiovascular events.A best case scenario analysis using a Markov was conducted.8.67% 50-79 year olds who regularly consume in China, including individuals without prior diagnosis hypertension.The simulated potential impact daily intake two servings (+700 mg/day) vs consumption fortification, assuming market price equal 0.99 international dollars...
Abstract 129 Xe N.M.R. has been used to investigate intermolecular interactions between xenon and different crown ethers. Chemical shifts of this isotope measured in chloroform solutions containing various amounts glymes ethers show that the behaviour cyclic molecules is qualitatively very from their linear analogues. Experimental data are interpreted frame a 2− 3‐site model developed for respectively. Our results support existence loosely bound host‐guest pair characterized by an...
This study evaluated the cost-effectiveness of consumption a milk powder product fortified with potassium (+1050.28 mg/day) and phytosterols (+1200 to lower systolic blood pressure low-density lipoprotein cholesterol, respectively, and, therefore, risk myocardial infarction (MI) stroke among 35-75-year-old population in Malaysia. A Markov model was created against do-nothing option, from governmental perspective, time horizon 40 years. Different data sources, encompassing clinical studies,...
Abstract The NMR anisochrony which characterizes the diastereotopism of CH 3 groups in an isopropyl group attached to a chiral residue is defined not only magnitude but also sign. absolute signs anisochronies were determined for two series derivatives type XYZC‐CH(CH ) 2 . Sign inversions observed number compounds belonging same homologous when compared by 1 H or 13 C spectroscopy.
Abstract The intermolecular Overhauser effect { 1 H} 13 C is studied on two binary systems chloroform/carbon disulfide and chloroform/acetone. Some comments are made concerning the use of these measurements for study interactions in solution.