A5102752037- Nitric Oxide and Endothelin Effects
- Diamond and Carbon-based Materials Research
- Cardiovascular and exercise physiology
- High-pressure geophysics and materials
- Muscle activation and electromyography studies
- Geological and Geochemical Analysis
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- 3D Printing in Biomedical Research
- Pulmonary Hypertension Research and Treatments
- Soft tissue tumor case studies
- Force Microscopy Techniques and Applications
- IgG4-Related and Inflammatory Diseases
- Supply Chain Resilience and Risk Management
- Inflammatory Myopathies and Dermatomyositis
- Infrastructure Resilience and Vulnerability Analysis
- Laser-Plasma Interactions and Diagnostics
- Glaucoma and retinal disorders
- Medical Imaging Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- Cardiovascular Effects of Exercise
- Information and Cyber Security
Stanford University
2024
Brigham Young University
2024
Wrightington Hospital
2021
Queen Alexandra Hospital
2015
A.T. Still University
2004-2005
In vivo molecular imaging tools are crucially important for elucidating how cells move through complex biological systems; however, achieving single-cell sensitivity over the entire body remains challenging. Here, we report a highly sensitive and multiplexed approach tracking upward of 20 single simultaneously in same subject using positron emission tomography (PET). The method relies on statistical algorithm (PEPT-EM) to achieve 4 becquerel per cell streamlined workflow reliably label with...
We report successful coupling of dynamic loading in a diamond anvil cell and stable laser heating, which enables compression rates up to 500 GPa/s along high-temperature isotherms. Dynamic diamond-anvil allows exploration wider range pathways the pressure-temperature space compared conventional techniques. By x-ray diffraction, we are able characterize monitor structural transitions with appropriate time resolution i.e., millisecond timescales. Using this method, investigate <a:math...
<title>Abstract</title> <italic>Decades of research have investigated the mechanical properties matter under extreme conditions, exploring how materials deform, yield, and fail when subjected to high strain rates. While plasticity codes computational methods can provide atomic-scale precision, reliable experimental benchmarks are needed validate these models. However, for decades only bulk surface measurements (e.g., velocimetry reflectivity) were available community, data interpretation was...
While a natural disaster or related threat may impact an organisation at some point, it is more likely (even inevitable) that will be the victim of cyber attack. The solution to being better prepared for these imminent attacks undertake lightweight and frequent incident response (IR) exercises help build capabilities community through tighter, recurring cycle planning, conducting assessing. To boost facilitation IR exercises, organisations must leverage established relationships between...
We report on a novel approach to dynamic compression of materials that bridges the gap between previous static- and dynamic- techniques, allowing explore wide range pathways in pressure-temperature space. By combining dynamic-diamond anvil cell setup with double-sided laser-heating situ X-ray diffraction, we are able perform at high temperature characterize structural transitions unprecedented time resolution. Using this method, investigate $\gamma-\epsilon$ phase transition iron under for...
During skeletal muscle contractions microvascular PO2 (PO2m) falls reflecting the fact that oxygen consumption outstrips delivery in face of elevated blood flow. With cessation contractions, PO2m rises back towards pre-contraction levels, reduction an Nitric oxide (NO) production is important vasodilator working and also thought to be involved regulation contractile activity. PURPOSE The purpose this study was test hypothesis inhibition NO synthase will create a mismatch between during...
The rate of change in microvascular PO2 (PO2m) at the onset skeletal muscle contractions (on-kinetics) reflects dynamic balance between oxygen delivery and consumption. In muscle, nitric oxide (NO) is an important regulator both blood flow appears to play a role force production, which would impact PO2m. PURPOSE purpose this study was test hypothesis that inhibition NO synthase will accelerate PO2m on-kinetics contractions. METHODS (phosphorescence quenching) tension were measured EDL female...
0818 Despite the increase in blood flow, and therefore oxygen delivery (QO2), at onset of muscle contractions, there is a fall PO2m reflecting relatively greater uptake utilization (VO2). We recently observed that rate force production during twitch contractions increases with contraction frequency, suggesting more rapid VO2. PURPOSE: The purpose this study was to test hypothesis on-kinetics are frequency-dependent, tightly coupled development. METHODS: (measured using phosphorescence...
The rate of change in microvascular PO2 (PO2m) at the onset skeletal muscle contractions (on-kinetics) reflects dynamic balance between oxygen delivery and consumption. In muscle, nitric oxide (NO) is an important regulator both blood flow appears to play a role force production, which would impact PO2m. PURPOSE purpose this study was test hypothesis that inhibition NO synthase will accelerate PO2m on-kinetics contractions. METHODS (phosphorescence quenching) tension were measured EDL female...
0818 Despite the increase in blood flow, and therefore oxygen delivery (QO2), at onset of muscle contractions, there is a fall PO2m reflecting relatively greater uptake utilization (VO2). We recently observed that rate force production during twitch contractions increases with contraction frequency, suggesting more rapid VO2. PURPOSE: The purpose this study was to test hypothesis on-kinetics are frequency-dependent, tightly coupled development. METHODS: (measured using phosphorescence...
During skeletal muscle contractions microvascular PO2 (PO2m) falls reflecting the fact that oxygen consumption outstrips delivery in face of elevated blood flow. With cessation contractions, PO2m rises back towards pre-contraction levels, reduction an Nitric oxide (NO) production is important vasodilator working and also thought to be involved regulation contractile activity. PURPOSE The purpose this study was test hypothesis inhibition NO synthase will create a mismatch between during...
Focal myositis is a rare condition first described by Heffner et al., in 1977, as self-limiting of unknown aetiology. It presents an inflammatory pseudo tumour skeletal muscle and can present diagnostic difficulty, being commonly mistaken for tissue vascular, inflammatory, or neoplastic origin. Diagnosis traditionally confirmed biopsy. We case where magnetic resonance imaging (MRI) was used to confirm the diagnosis without need biopsy.A 19-year year-old female presented with two2-year...